objective: infantile spasm is an age dependent ant myoclonic seizure which occurs in 25 per 100,000 live births. we aimed to investigate effect of intravenous methypredinsolone pulse on the infantile spasm in patients hospitalized in 17 shahrivar hospital, rasht. materials and methods: this is an observational case series which was conducted on 20 infants with infantile spasms hospitalized in 1...

background considering the inadequacies of current therapeutic regimens for infantile spasms (is), and the frequent and serious side effects of  some regimens, the ongoing search for more enhanced protocols is understandable. materials and methods: we have compared the therapeutic and adverse effects of vitamin b6 given in high doses with those of prednisolone in a randomized controlled clinica...

Background: Infantile spasm is a type of pediatric seizure often associated with a negative prognosis. The aim of this study was to evaluate the role of Magnetic Resonance Imaging (MRI) in categorization and neurodevelopmental outcomes in children with infantile spasm. Materials and Methods: A retrospective study of the clinical charts and MRI findings of infants diagnosed with infantile spasm ...

Infantile spasm is an age-related refractory epilepsy. Topiramate is a new anticonvulsant with multiple mechanisms of action, and it may be effective for treating pediatric epilepsies. To evaluate the efficacy and tolerability of first-line topiramate treatment for infantile spasm, 20 patients received topiramate monotherapy during this study. They were treated with an initial dose of 1mg/kg/da...

PURPOSE Infantile spasm is an age-dependent epileptic syndrome seen in infancy or early childhood. Although studies have investigated the epilepsy-cytokine relationship, there has been insufficient research into the relation between cytokines and infantile spasm. The purpose of this study was to examine the role of cytokines in the pathogenesis of infantile spasm by investigating cytokine level...

how to cite this article: taghdiri mm, nemati h. infantile spasm: a review article. iran j child neurol. 2014 summer;8(3): 1-5. abstract objective infantile spasm (is) is a convulsive disease characterized by brief, symmetric axial muscle contraction (neck, trunk, and/or extremities). is is a type of seizure that was first described by west in 1841, who witnessed the seizure in his own son. wes...

Background Infantile spasm is a rare condition in infants from 4 to 7 months old. Treatment varies in different cases. Corticosteroids and adrenocorticotropic hormone (ACTH) are the most widely used treatment options; however, there are debates on their efficacy. The aim of our study is to compare corticosteroid treatment with ACTH in patients with infantile spasm. Materials and Me...

Twenty six patients were diagnosed as infantile spasm, on the basis of fixed criteria and they were divided into symptomatic (17 patients) and cryptogenic (9 patients) groups according to history, presentation and investigations. Corticotrophin as Tetracosactrin was given to eleven patients and fifteen patients received Vigabatrim (VGB). The response to VGB was significant (73%) compared to ste...